Article
Distinct Phenotypes of Cigarette Smokers Identified by Cluster Analysis of Patients with Severe Asthma.
Annals of the American Thoracic Society - 1 Dec 2015
Konno Satoshi, Taniguchi Natsuko, Makita Hironi, Nakamaru Yuji, Shimizu Kaoruko, Shijubo Noriharu, Fuke Satoshi, Takeyabu Kimihiro, Oguri Mitsuru, Kimura Hirokazu, Maeda Yukiko, Suzuki Masaru, Nagai Katsura, Ito Yoichi M, Wenzel Sally E, Nishimura Masaharu
Abstract excerpt
RATIONALE: Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asthma. Cluster analysis has been applied to explore novel phenotypes, which are not based on any a priori hypotheses. OBJECTIVES: To explore novel severe asthma phenotypes by cluster analysis when including cigarette smokers. METHODS: We recruited a total of 127 subjects with severe asthma, including 59 current or...
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