Article
Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2015
Becker K L, Gresnigt M S, Smeekens S P, Jacobs C W, Magis-Escurra C, Jaeger M, Wang X, Lubbers R, Oosting M, Joosten L A B, Netea M G, Reijers M H, van de Veerdonk F L
Abstract excerpt
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is characterised by an exaggerated Th2 response to Aspergillus fumigatus, but the immunological pathways responsible for this effect are unknown. OBJECTIVE: The aim of this study was to decipher the pattern recognition receptors (PRRs) and cytokines involved in the Aspergillus-specific Th2 response and to study Aspergillus-induced responses in healthy...
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