Article
Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells.
The Journal of infection - 1 Jan 2017
Jolink Hetty, de Boer Renate, Hombrink Pleun, Jonkers René E, van Dissel Jaap T, Falkenburg J H Frederik, Heemskerk Mirjam H M
Abstract excerpt
In healthy individuals and in patients with invasive aspergillosis, Aspergillus-specific T-cells in peripheral blood display mainly a Thelper1 phenotype. Although in other fungal infections Thelper17 immunity is important, it was suggested that in aspergillus infection Thelper17 cells do not play a role or may even be detrimental. OBJECTIVES: To compare the cytokine profiles of Aspergillus-specific CD4+ T-cells...
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