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Article

Epigenetic regulation of metalloproteinases and their inhibitors in rotator cuff tears

13 Sept 2017

Abstract excerpt

Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28902861
DOI: 10.1371/journal.pone.0184141

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