Article
Matrix Metalloproteases 1 and 3 Promoter Gene Polymorphism Is Associated With Rotator Cuff Tear.
Clinical orthopaedics and related research - 1 Jul 2017
Assunção Jorge H, Godoy-Santos Alexandre L, Dos Santos Maria Cristina L G, Malavolta Eduardo A, Gracitelli Mauro E C, Ferreira Neto Arnaldo A
Abstract excerpt
BACKGROUND: Studies suggest that the collagen degeneration and disordered arrangement of collagen fibers in rotator cuff tears are associated with an increase in activity of matrix metalloproteases 1 and 3 (MMP-1 and MMP-3), and that MMP activity may be in part genetically mediated. The degree to which this might be clinically relevant in patients with rotator cuff tears has not been well characterized....
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