Article
Next Generation Sequencing Plus (NGS+) with Y-chromosomal Markers for Forensic Pedigree Searches.
Scientific reports - 12 Sept 2017
Qian Xiaoqin, Hou Jiayi, Wang Zheng, Ye Yi, Lang Min, Gao Tianzhen, Liu Jing, Hou Yiping
Abstract excerpt
There is high demand for forensic pedigree searches with Y-chromosome short tandem repeat (Y-STR) profiling in large-scale crime investigations. However, when two Y-STR haplotypes have a few mismatched loci, it is difficult to determine if they are from the same male lineage because of the high mutation rate of Y-STRs. Here we design a new strategy to handle cases in which none of pedigree samples shares...
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