Article
Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2023
Pajoumshariati Ramin, Ewart Lorna, Kujala Ville, Luc Raymond, Peel Samantha, Corrigan Adam, Weber Heather, Nugraha Bramasta, Hansen Pernille B L, Williams Julie
Abstract excerpt
The function of the glomerulus depends on the complex cell-cell/matrix interactions and replication of this in vitro would aid biological understanding in both health and disease. Previous models do not fully reflect all cell types and interactions present as they overlook mesangial cells within their 3D matrix. Herein, the development of a microphysiological system that contains all resident renal cell types in...
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