Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of allopurinol resistance in Leishmania infantum isolated from dogs.

PLoS neglected tropical diseases - 1 Sept 2017

Yasur-Landau Daniel, Jaffe Charles L, Doron-Faigenboim Adi, David Lior, Baneth Gad

Abstract excerpt

Resistance to allopurinol in zoonotic canine leishmaniasis has been recently shown to be associated with disease relapse in naturally-infected dogs. However, information regarding the formation of resistance and its dynamics is lacking. This study describes the successful in-vitro induction of allopurinol resistance in Leishmania infantum cultured under increasing drug pressure. Allopurinol susceptibility and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiprotozoal Agents
Share to Allopurinol
Share to Dog Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Inhibitory Concentration 50

Share to Leishmania infantum

Share to Leishmaniasis, Visceral

Source

Open in PubMed Open full text

Identifiers

PMID: 28892476
DOI: 10.1371/journal.pntd.0005910
PMCID: PMC5608428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of allopurinol resistance in Leishmania infantum isolated from dogs.PMID 28892476Read ↗

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy numberSemantic proximity Read ↗

Direct quantitative PCR detects genetic biomarkers of antileishmanial drug resistance in clinical samples from dogs with leishmaniosisSemantic proximity Read ↗

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.Semantic proximity Read ↗

Direct quantitative PCR detects genetic biomarkers of antileishmanial drug resistance in clinical samples from dogs with leishmaniosisSemantic proximity Read ↗

Treatment of canine visceral leishmaniasis with Milteforan <sup>™</sup> induces <i>Leishmania infantum</i> resistance to miltefosine and amphotericin BSemantic proximity Read ↗

Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markersSemantic proximity Read ↗

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantumSemantic proximity Read ↗

MRPA-independent mechanisms of antimony resistance in Leishmania infantum.Semantic proximity Read ↗

Experimental Induction of Paromomycin Resistance in Antimony-Resistant Strains of L. donovani: Outcome Dependent on In Vitro Selection ProtocolSemantic proximity Read ↗

Phenotypic characterization of Leishmania mexicana pentamidine-resistant promastigotes. Modulation of the resistance during in-vitro developmental life cycle.Semantic proximity Read ↗

Multiple Drug Resistance in the canine hookworm <i>Ancylostoma caninum</i> : an Emerging ThreatSemantic proximity Read ↗

The emergence of drug-resistant malaria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.