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Article

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

8 Sept 2017

Abstract excerpt

Abstract Autophagy mediates resistance to various anticancer agents. In melanoma, resistance to targeted therapy has been linked to expression of Wnt5A, an intrinsic inhibitor of β-catenin, which also promotes invasion. In this study, we assessed the interplay between Wnt5A and autophagy by combining expression studies in human clinical biopsies with functional analyses in cell lines and mouse models. Melanoma...

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PMID: 28887323
DOI: 10.1158/0008-5472.can-17-0907

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