Article
Macromolecular Assemblies of the Mammalian Circadian Clock.
Molecular cell - 7 Sept 2017
Aryal Rajindra P, Kwak Pieter Bas, Tamayo Alfred G, Gebert Michael, Chiu Po-Lin, Walz Thomas, Weitz Charles J
Abstract excerpt
The mammalian circadian clock is built on a feedback loop in which PER and CRY proteins repress their own transcription. We found that in mouse liver nuclei all three PERs, both CRYs, and Casein Kinase-1δ (CK1δ) are present together in an ∼1.9-MDa repressor assembly that quantitatively incorporates its CLOCK-BMAL1 transcription factor target. Prior to incorporation, CLOCK-BMAL1 exists in an ∼750-kDa complex....
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