Article
MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2.
PloS one - 1 Jan 2017
Rangrez Ashraf Yusuf, Hoppe Phillip, Kuhn Christian, Zille Elisa, Frank Johanne, Frey Norbert, Frank Derk
Abstract excerpt
Calsarcin-1 deficient mice develop dilated cardiomyopathy (DCM) phenotype in pure C57BL/6 genetic background (Cs1-ko) despite severe contractile dysfunction and robust activation of fetal gene program. Here we performed a microRNA microarray to identify the molecular causes of this cardiac phenotype that revealed the dysregulation of several microRNAs including miR-301a, which was highly downregulated in Cs1-ko...
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