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Article

Testing the face shape hypothesis in twins discordant for nonsyndromic orofacial clefting.

American journal of medical genetics. Part A - 1 Nov 2017

Roosenboom Jasmien, Indencleef Karlijne, Hens Greet, Peeters Hilde, Christensen Kaare, Marazita Mary L, Claes Peter, Leslie Elizabeth J, Weinberg Seth M

Abstract excerpt

Nonsyndromic orofacial clefts (OFCs) are complex traits characterized by multifactorial inheritance and wide phenotypic variability. Numerous studies have shown subtle differences in the faces of unaffected relatives from cleft families compared to controls, the implication being that such outward differences are an incomplete expression reflecting an underlying genetic predisposition. Twins discordant for OFCs...

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Source

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Identifiers

PMID: 28884971
DOI: 10.1002/ajmg.a.38471
PMCID: PMC5725745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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