Article
Subjective memory complaints in preclinical autosomal dominant Alzheimer disease.
Neurology - 3 Oct 2017
Norton Daniel J, Amariglio Rebecca, Protas Hillary, Chen Kewei, Aguirre-Acevedo Daniel C, Pulsifer Brendan, Castrillon Gabriel, Tirado Victoria, Munoz Claudia, Tariot Pierre, Langbaum Jessica B, Reiman Eric M, Lopera Francisco, Sperling Reisa A, Quiroz Yakeel T
Abstract excerpt
OBJECTIVE: To cross-sectionally study subjective memory complaints (SMC) in autosomal dominant Alzheimer disease (ADAD). METHODS: We examined self-reported and study partner-based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD. Twenty-six carried the PSEN-1 E280A mutation, averaging 7 years of age younger than the kindred's expected clinical onset. Twenty-six...
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