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Article

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability.

Science translational medicine - 6 Sept 2017

Kirk Joseph A, Gebhart Dana, Buckley Anthony M, Lok Stephen, Scholl Dean, Douce Gillian R, Govoni Gregory R, Fagan Robert P

Abstract excerpt

There is a medical need for antibacterial agents that do not damage the resident gut microbiota or promote the spread of antibiotic resistance. We recently described a prototypic precision bactericidal agent, Av-CD291.2, which selectively kills specific Clostridium difficile strains and prevents them from colonizing mice. We have since selected two Av-CD291.2-resistant mutants that have a surface (S)-layer-null...

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Source

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Identifiers

PMID: 28878013
DOI: 10.1126/scitranslmed.aah6813
PMCID: PMC5603275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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