The role of histone modification and a regulatory single-nucleotide polymorphism (rs2071166) in the Cx43 promoter in patients with TOF.

doi:10.1038/s41598-017-10756-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The role of histone modification and a regulatory single-nucleotide polymorphism (rs2071166) in the Cx43 promoter in patients with TOF.

Scientific reports - 5 Sept 2017

Gu Ruoyi, Xu Jun, Lin Yixiang, Sheng Wei, Ma Duan, Ma Xiaojing, Huang Guoying

Abstract excerpt

Abnormal level of Cx43 expression could result in CHD. Epigenetic modification and disease-associated, non-coding SNPs might influence gene transcription and expression. Our study aimed to determine the role of histone modification and an rSNP (rs2071166) in the Cx43 promoter in patients with TOF. Our results indicate that H3K18ac bind to Cx43 promoter and that their levels are reduced in TOF patients relative to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexin 43

Share to Histone Code

Share to Histones

Share to Immunohistochemistry

Share to Lysine

Share to Retinoid X Receptor alpha

Share to Tetralogy of Fallot

Source

Open in PubMed Open full text

Identifiers

PMID: 28874875
DOI: 10.1038/s41598-017-10756-6
PMCID: PMC5585261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of histone modification and a regulatory single-nucleotide polymorphism (rs2071166) in the Cx43 promoter in patients with TOF.PMID 28874875Read ↗

Rs4759314 polymorphism located in HOTAIR is associated with the risk of congenital heart disease by alternating downstream signaling via reducing its expression.Semantic proximity Read ↗

Identification of SOX18 as a New Gene Predisposing to Congenital Heart DiseaseSemantic proximity Read ↗

Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of FallotSemantic proximity Read ↗

Tetralogy of Fallot: variants of MYH6 gene promoter and cellular functional analyses.Semantic proximity Read ↗

The pathophysiological role of novel pulmonary arterial hypertension gene SOX17.Semantic proximity Read ↗

Synonymous variants in IRX4 and their association with congenital heart disease: an in-silico functional assessment.Semantic proximity Read ↗

Association of Cx43 rs2071166 polymorphism with an increased risk for atrial septal defect.Semantic proximity Read ↗

Novel and functional variants within the TBX18 gene promoter in ventricular septal defects.Semantic proximity Read ↗

Three rare variants of SOX7 impairing its interaction with GATA4 may be a predisposing factor to complete AVSDSemantic proximity Read ↗

Functional polymorphisms of the neuropilin 1 gene are associated with the risk of tetralogy of Fallot in a Chinese Han population.Semantic proximity Read ↗

Novel mutations of the SRF gene in Chinese sporadic conotruncal heart defect patientsSemantic proximity Read ↗

Identification and analysis of KLF13 variants in patients with congenital heart diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.