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Article

Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients.

Journal of the neurological sciences - 15 Sept 2017

Li Yanzhi, Zhang Zhengsheng, Deng Linglong, Bai Feng, Shi Yongmei, Yu Hui, Xie Chunming, Yuan Yonggui, Zhang Zhijun

Abstract excerpt

Angiotensin-converting enzyme (ACE) gene has been implicated in amnestic mild cognitive impairment (aMCI). Most human genetic studies have focused on ACE insertion (I)/deletion (D) polymorphism and yielded conflicting results. In this work, we evaluated the relationships between cognitive function, serum ACE level, brain white matter (WM) integrity, and ACE I/D polymorphism in 48 patients with aMCI and 36 well...

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Identifiers

PMID: 28870562
DOI: 10.1016/j.jns.2017.06.026

Genes

ACE

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Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients.PMID 28870562Read ↗

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