Article
Targeted next-generation sequencing of glandular odontogenic cyst: a preliminary study.
Oral surgery, oral medicine, oral pathology and oral radiology - 1 Nov 2017
Siqueira Elisa Carvalho de, de Sousa Silvia Ferreira, França Josiane Alves, Diniz Marina Gonçalves, Pereira Thaís Dos Santos Fontes, Moreira Rennan Garcias, Vargas Pablo Agustin, Gomez Ricardo Santiago, Gomes Carolina Cavalieri
Abstract excerpt
OBJECTIVE: Glandular odontogenic cyst (GOC) is an uncommon developmental cyst. Its molecular pathogenesis is unclear, and deep sequencing may help identify causative low-frequency variants in tumors. We investigated in GOC mutations in 50 genes commonly altered in human cancers. STUDY DESIGN: Targeted next-generation sequencing was used to interrogate a panel of approximately 2800 mutations in GOC. RESULTS: Six...
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