Article
A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents.
Cold Spring Harbor molecular case studies - 1 Sept 2017
Wilkes David C, Sailer Verena, Xue Hui, Cheng Hongwei, Collins Colin C, Gleave Martin, Wang Yuzhuo, Demichelis Francesca, Beltran Himisha, Rubin Mark A, Rickman David S
Abstract excerpt
Defects in genes involved in DNA damage repair (DDR) pathway are emerging as novel biomarkers and targets for new prostate cancer drug therapies. A previous report revealed an association between an exceptional response to cisplatin treatment and a somatic loss of heterozygosity (LOH) of FANCA in a patient with metastatic prostate cancer who also harbored a germline FANCA variant (S1088F). Although germline FANCA...
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