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Article

Tumor progression in DICER1-mutated cystic nephroma-witnessing the genesis of anaplastic sarcoma of the kidney.

Human pathology - 1 Jul 2016

Wu Mona K, Cotter Maura B, Pears Jane, McDermott Michael B, Fabian Marc R, Foulkes William D, O'Sullivan Maureen J

Abstract excerpt

We report a 7-month-old female infant with a multicystic left renal tumor having histologic features predominantly of a cystic nephroma, but with microscopic cellular foci which contained atypical mitotic figures and anaplastic nuclei. Immunohistochemistry showed strong p53 reactivity in the anaplastic region. DICER1 sequencing confirmed 2 mutations: germ line mutation c.2450delC and c.5438A>G somatic within the...

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Source

Identifiers

PMID: 27036314
DOI: 10.1016/j.humpath.2016.03.002

Genes

DICER1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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