Article
Neurofibromin C terminus-specific antibody (clone NFC) is a valuable tool for the identification of NF1-inactivated GISTs.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2018
Rossi Sabrina, Gasparotto Daniela, Cacciatore Matilde, Sbaraglia Marta, Mondello Alessia, Polano Maurizio, Mandolesi Alessandra, Gronchi Alessandro, Reuss David E, von Deimling Andreas, Maestro Roberta, Dei Tos Angelo Paolo
Abstract excerpt
An increasing body of evidence supports the involvement of NF1 mutations, constitutional or somatic, in the pathogenesis of gastrointestinal stromal tumors (GISTs). Due to the large size of the NF1 locus, the existence of multiple pseudogenes and the wide spectrum of mechanisms of gene inactivation, the analysis of NF1 gene status is still challenging for most laboratories. Here we sought to assess the efficacy...
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