Article
Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms.
Acta neuropathologica - 1 Apr 2014
Reuss David E, Habel Antje, Hagenlocher Christian, Mucha Jana, Ackermann Ulrike, Tessmer Claudia, Meyer Jochen, Capper David, Moldenhauer Gerhard, Mautner Victor, Frappart Pierre-Olivier, Schittenhelm Jens, Hartmann Christian, Hagel Christian, Katenkamp Kathrin, Petersen Iver, Mechtersheimer Gunhild, von Deimling Andreas
Abstract excerpt
Malignant peripheral nerve sheath tumors (MPNST) derive from the Schwann cell or perineurial cell lineage and occur either sporadically or in association with the tumor syndrome neurofibromatosis type 1 (NF1). MPNST often pose a diagnostic challenge due to their frequent lack of pathognomonic morphological or immunohistochemical features. Mutations in the NF1 tumor suppressor gene are found in all NF1-associated...
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