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Article

Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis.

Annals of neurology - 1 Sept 2017

El Oussini Hajer, Scekic-Zahirovic Jelena, Vercruysse Pauline, Marques Christine, Dirrig-Grosch Sylvie, Dieterlé Stéphane, Picchiarelli Gina, Sinniger Jérôme, Rouaux Caroline, Dupuis Luc

Abstract excerpt

OBJECTIVE: Spasticity occurs in a wide range of neurological diseases, including neurodegenerative diseases, after trauma, and after stroke, and is characterized by increased reflexes leading to muscle hypertonia. Spasticity is a painful symptom and can severely restrict everyday life, but might also participate in maintaining a low level of motor function in severely impaired patients. Constitutive activity of...

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Identifiers

PMID: 28856708
DOI: 10.1002/ana.25030

Genes

SOD1
TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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