Article
An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis
30 Aug 2017
Abstract excerpt
Significance We present an epigenetic switch in the central control of reproduction as a truncated TET1, expressed in proliferating gonadotrope-precursor cells, which inhibits Lhb expression and so must be repressed for reproductive development. Expression of this TET1 isoform is regulated by cis -elements mediating effects of gonadal steroids and PKA, and also a potentially methylated distal enhancer. As this...