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Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections

13 Jun 2017

Abstract excerpt

ABSTRACT There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing signal biosynthesis, a process that is conserved in Gram-positive bacterial pathogens. Some...

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Share to Antimicrobial Resistance in Staphylococcus
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PMID: 28607020
DOI: 10.1128/aac.00263-17

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