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Article

Single nucleotide polymorphisms at miR-146a/196a2 and their primary ovarian insufficiency-related target gene regulation in granulosa cells.

PloS one - 1 Jan 2017

Cho Sung Hwan, An Hui Jeong, Kim Kyung Ah, Ko Jung Jae, Kim Ji Hyang, Kim Young Ran, Ahn Eun Hee, Rah HyungChul, Lee Woo Sik, Kim Nam Keun

Abstract excerpt

MicroRNAs post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to identify new target genes for microRNA polymorphisms (miR-146aC>G and miR-196a2T>C) in primary ovarian insufficiency (POI). We cloned and transfected miR-146aC>G and miR-196a2T>C into human granulosa cells and used microarrays and qPCR-arrays to examine the changes in the messenger RNA expression profile....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28841705
DOI: 10.1371/journal.pone.0183479
PMCID: PMC5571913

Genes

CCND2
FOXO3
FOXL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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