Article
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.
ACS chemical biology - 20 Oct 2017
Falchi Federico, Giacomini Elisa, Masini Tiziana, Boutard Nicolas, Di Ianni Lorenza, Manerba Marcella, Farabegoli Fulvia, Rossini Lara, Robertson Janet, Minucci Saverio, Pallavicini Isabella, Di Stefano Giuseppina, Roberti Marinella, Pellicciari Roberto, Cavalli Andrea
Abstract excerpt
In BRCA2-defective cells, poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitors can trigger synthetic lethality, as two independent DNA-repairing mechanisms are simultaneously impaired. Here, we have pharmacologically induced synthetic lethality, which was triggered by combining two different small organic molecules. When administered with a BRCA2-Rad51 disruptor in nonmutant cells, Olaparib showed...
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