Article
Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Apr 2014
Au Anthony, Aziz Baba Abdul, Goh Ai Sim, Wahid Fadilah S Abdul, Teh Alan, Rosline Hassan, Ankathil Ravindran
Abstract excerpt
The introduction and success of imatinib mesylate (IM) has become a paradigm shift in chronic myeloid leukemia (CML) treatment. However, the high efficacy of IM has been hampered by the issue of clinical resistance that might due to pharmacogenetic variability. In the current study, the contribution of three common single nucleotide polymorphisms (SNPs) of ABCB1 (T1236C, G2677T/A and C3435T) and two SNPs of ABCG2...
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