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Article

Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Oct 2017

Angelousi Anna, Szarek Eva, Shram Vincent, Kebebew Electron, Quezado Martha, Stratakis Constantine A

Abstract excerpt

The adrenal cortex accumulates lipofuscin granules with age. Lipofuscin accumulation is also seen in adrenocortical tumors associated with Cushing syndrome (CS), particularly those with PRKAR1A mutations, such as in primary pigmented nodular adrenocortical disease (PPNAD). We investigated the presence of lipofuscin in cortisol-producing adenomas (CPAs) responsible for CS with and without the PRKACA (pLeu206Arg)...

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Identifiers

PMID: 28834963
DOI: 10.1055/s-0043-116385
PMCID: PMC6299839

Genes

PRKACA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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