Article
New insights into HCV replication in original cells from Aedes mosquitoes.
Virology journal - 22 Aug 2017
Fallecker Catherine, Caporossi Alban, Rechoum Yassine, Garzoni Frederic, Larrat Sylvie, François Olivier, Fender Pascal, Morand Patrice, Berger Imre, Petit Marie-Anne, Drouet Emmanuel
Abstract excerpt
BACKGROUND: The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glycoproteins to bind on Aedes mosquito cells and (ii) the ability of HCV serum particles (HCVsp) to replicate in these cell lines. METHODS: First, we used purified E1E2 expressing baculovirus-derived...
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