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Article

Daw1 regulates the timely onset of cilia motility during development.

Development (Cambridge, England) - 15 Jun 2022

Bearce Elizabeth A, Irons Zoe H, Craig Samuel B, Kuhns Colin J, Sabazali Cynthia, Farnsworth Dylan R, Miller Adam C, Grimes Daniel T

Abstract excerpt

Motile cilia generate cell propulsion and extracellular fluid flows that are crucial for airway clearance, fertility and left-right patterning. Motility is powered by dynein arm complexes that are assembled in the cytoplasm then imported into the cilium. Studies in Chlamydomonas reinhardtii showed that ODA16 is a cofactor which promotes dynein arm import. Here, we demonstrate that the zebrafish homolog of ODA16,...

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Identifiers

PMID: 35708608
DOI: 10.1242/dev.200017
PMCID: PMC9270974

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