Titin-Truncating Variants Increase the Risk of Cardiovascular Death in Patients With Hypertrophic Cardiomyopathy.

doi:10.1016/j.cjca.2017.05.020

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Article

Titin-Truncating Variants Increase the Risk of Cardiovascular Death in Patients With Hypertrophic Cardiomyopathy.

The Canadian journal of cardiology - 1 Oct 2017

Zhang Ce, Zhang Hongju, Wu Guixin, Luo Xiaoliang, Zhang Channa, Zou Yubao, Wang Hu, Hui Rutai, Wang Jizheng, Song Lei

Abstract excerpt

BACKGROUND: Titin-truncating variants (TTNtv) have been detected in a variety of cardiomyopathies and represent the most common cause of dilated cardiomyopathy. However, their significance in hypertrophic cardiomyopathy (HCM) is still unclear. METHODS: The titin gene (TTN) was sequenced for truncating variants in a cohort of 529 Chinese patients with HCM and 307 healthy controls. Baseline and follow-up clinical...

Topics

Adult
Cardiomyopathy, Hypertrophic
China
Connectin
DNA
DNA Mutational Analysis
Databases, Genetic
Female
Follow-Up Studies
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Polymerase Chain Reaction

Retrospective Studies

Survival Rate

Time Factors

Transcription, Genetic

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Open in PubMed

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PMID: 28822653
DOI: 10.1016/j.cjca.2017.05.020

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