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Article

Titin-Truncating Variants Increase the Risk of Cardiovascular Death in Patients With Hypertrophic Cardiomyopathy.

The Canadian journal of cardiology - 1 Oct 2017

Zhang Ce, Zhang Hongju, Wu Guixin, Luo Xiaoliang, Zhang Channa, Zou Yubao, Wang Hu, Hui Rutai, Wang Jizheng, Song Lei

Abstract excerpt

BACKGROUND: Titin-truncating variants (TTNtv) have been detected in a variety of cardiomyopathies and represent the most common cause of dilated cardiomyopathy. However, their significance in hypertrophic cardiomyopathy (HCM) is still unclear. METHODS: The titin gene (TTN) was sequenced for truncating variants in a cohort of 529 Chinese patients with HCM and 307 healthy controls. Baseline and follow-up clinical...

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Source

Identifiers

PMID: 28822653
DOI: 10.1016/j.cjca.2017.05.020

Genes

TTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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