Article
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.
Gut microbes - 2 Jan 2018
Rühlemann Malte C, Degenhardt Frauke, Thingholm Louise B, Wang Jun, Skiecevičienė Jurgita, Rausch Philipp, Hov Johannes R, Lieb Wolfgang, Karlsen Tom H, Laudes Matthias, Baines John F, Heinsen Femke-Anouska, Franke Andre
Abstract excerpt
Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be...
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