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Article

Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9.

Scientific reports - 15 Aug 2017

Zhang Xuemei, Li Wenrong, Liu Chenxi, Peng Xinrong, Lin Jiapeng, He Sangang, Li Xuejiao, Han Bing, Zhang Ning, Wu Yangsheng, Chen Lei, Wang Liqin, MaYila, Huang Juncheng, Liu Mingjun

Abstract excerpt

Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9. A total of seven indels were identified in 5 of 6 born lambs. Each targeted lamb happened at least two kinds of modifications, and targeted lambs with multiple modifications displayed variety...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28811591
DOI: 10.1038/s41598-017-08636-0
PMCID: PMC5557758

Genes

ASIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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