Article
Ponatinib-Induced Graft-versus-Host Disease/Graft-versus-Leukemia Effect in a Patient with Philadelphia-Positive Acute Lymphoblastic Leukemia without the T315I Mutation Relapsing after Allogeneic Transplant.
Chemotherapy - 1 Jan 2017
Petrungaro Annamaria, Gentile Massimo, Mazzone Carla, Greco Rosa, Uccello Giuseppina, Recchia Anna Grazia, De Stefano Laura, Bossio Sabrina, Palummo Angela, Morelli Rosellina, Musolino Caterina, Morabito Fortunato, Vigna Ernesto
Abstract excerpt
We describe the case of a patient with Philadelphia-positive acute lymphoblastic leukemia treated with dasatinib plus steroids as first-line therapy, who achieved a major molecular response (MMR) before undergoing matched, unrelated donor allogeneic stem cell transplant. Eleven months after the transplant, she experienced molecular relapse. Mutational screening showed negativity for the T315I mutation, The...
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