Article
Ponatinib Induces a Persistent Molecular Response and Graft-versus-Host Disease/Graft-versus-Leukemia Effect in a Patient with Philadelphia-Positive Acute Lymphoblastic Leukemia with a T315I Mutation following Early Relapse after Allogeneic Transplant.
Chemotherapy - 1 Jan 2017
Renzi Daniela, Marchesi Francesco, De Angelis Gottardo, Elia Loredana, Salvatorelli Emanuela, Gumenyuk Svitlana, Palombi Francesca, Pisani Francesco, Romano Atelda, Spadea Antonio, Papa Elena, Canfora Marco, Arcese William, Mengarelli Andrea
Abstract excerpt
We describe the case of a patient with a Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) treated with dasatinib plus steroids as the first-line therapy who achieved a molecular complete remission and then underwent a matched, unrelated donor allogeneic transplant. Five months after the transplant, he experienced a disease relapse with an T315I mutation, which was resistant to salvage chemotherapy....
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