Article
Overall survival with ponatinib versus allogeneic stem cell transplantation in Philadelphia chromosome-positive leukemias with the T315I mutation.
Cancer - 1 Aug 2017
Nicolini Franck E, Basak Grzegorz W, Kim Dong-Wook, Olavarria Eduardo, Pinilla-Ibarz Javier, Apperley Jane F, Hughes Timothy, Niederwieser Dietger, Mauro Michael J, Chuah Charles, Hochhaus Andreas, Martinelli Giovanni, DerSarkissian Maral, Duh Mei Sheng, McGarry Lisa J, Kantarjian Hagop M, Cortes Jorge E
Abstract excerpt
BACKGROUND: Effective treatment options for patients with chronic myeloid leukemia (CML) or Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) who have the threonine to isoleucine mutation at codon 315 (T315I) are few. The objective of this study was to compare overall survival (OS) between patients with CML and those with Ph+ ALL who received treatment with ponatinib versus allogeneic stem cell...
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