Article
Estrogen receptor (ESR1) mutation in bone metastases from breast cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2018
Bartels Stephan, Christgen Matthias, Luft Angelina, Persing Sascha, Jödecke Kai, Lehmann Ulrich, Kreipe Hans
Abstract excerpt
Activating mutations of estrogen receptor α gene (ESR1) in breast cancer can cause endocrine resistance of metastatic tumor cells. The skeleton belongs to the metastatic sides frequently affected by breast cancer. The prevalence of ESR1 mutation in bone metastasis and the corresponding phenotype are not known. In this study bone metastases from breast cancer (n=231) were analyzed for ESR1 mutation. In 27 patients...
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