Article
Detection Mutations of JAK2 exon 12 in Patients with JAK2 (V617F)-negative Myeloproliferative Disorders.
The Gulf journal of oncology - 1 May 2017
Makani S Z, Parsamanesh N, Mirzaahmadi S, Hashemi M, Shaveisi-Zadeh F, Mansouri N, Ghazi M, Movafagh A
Abstract excerpt
BACKGROUND: Mutations in exon 12 of JAK2 gene are detected as clonal markers in hematopoietic lineages in myeloproliferative disorders (MPNs). Our aim was, to study the relation between N542-E543del mutation of JAK2 gene and myeloproliferative neoplasms in V617Fnegative patients. PATIENTS AND METHODS: DNA specimen from 34 patients and 44 healthy controls were genotyped using ARMs- PCR method. We analyzed exon 12...
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