Article
Detection of mutations in JAK2 exons 12-15 by Sanger sequencing.
International journal of laboratory hematology - 1 Feb 2016
Alghasham N, Alnouri Y, Abalkhail H, Khalil S
Abstract excerpt
INTRODUCTION: The Janus kinase (JAK)2 p.V617F gain-of-function mutation is a hallmark of BCR-ABL1-negative myeloproliferative neoplasms (MPNs). This study analyzed JAK2 mutations in 1811 patients tested between 2010 and 2013. METHODS: Exons 12-15 of JAK2 were sequenced in 1706 samples, and patients harboring mutations were clinically evaluated. RESULTS: Of 271 patients (16%) with JAK2 mutations, 148 (54.6%) were...
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