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Article

Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

9 Aug 2017

Abstract excerpt

BACKGROUND: Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism. METHODS: T cells were isolated from the blood of lupus patients. After stimulation with ionomycin or IL-15 and...

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PMID: 28793932
DOI: 10.1186/s13075-017-1393-y

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