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Article

Sirolimus in the treatment of three infants with diffuse congenital hyperinsulinism.

Journal of pediatric endocrinology & metabolism : JPEM - 28 Aug 2017

Al-Balwi Rana, Al-Atawi Mohsen, Al-Otaibi Ahlam, Babiker Omar, Al-Mutair Angham

Abstract excerpt

BACKGROUND: Congenital hyperinsulinism (CHI) is a major cause of persistent hypoglycemia and brain damage. Therapeutic strategies to avoid near total pancreatectomy in patients who are unresponsive to maximum doses of diazoxide and octreotide remain to be identified, although sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used successfully to treat diffuse type CHI. CASE PRESENTATION: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Inwardly Rectifying

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Share to Sulfonylurea Receptors

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Source

Identifiers

PMID: 28787272
DOI: 10.1515/jpem-2016-0229

Genes

KCNJ11
ABCC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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