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Article

mTOR Inhibitors for the Treatment of Severe Congenital Hyperinsulinism: Perspectives on Limited Therapeutic Success

3 Oct 2016

Abstract excerpt

CONTEXT: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in neonates and infants. In medically unresponsive CHI, subtotal pancreatectomy is performed to achieve euglycemia with consequent diabetes in later life. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been reported to obviate the need for pancreatectomy, but experience is limited. OBJECTIVE: We have...

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Share to Diabetes Management and Research
Share to Hyperglycemia and glycemic control in critically ill and hospitalized patients
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PMID: 27691052
DOI: 10.1210/jc.2016-2711

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