IL17A and IL23R gene polymorphisms affect the clinical features and prognosis of patients with multiple myeloma.

doi:10.1002/hon.2469

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Article

IL17A and IL23R gene polymorphisms affect the clinical features and prognosis of patients with multiple myeloma.

Hematological oncology - 1 Feb 2018

Kasamatsu Tetsuhiro, Kimoto Mari, Takahashi Noriyuki, Minato Yusuke, Gotoh Nanami, Takizawa Makiko, Matsumoto Morio, Sawamura Morio, Yokohama Akihiko, Handa Hiroshi, Tsukamoto Norifumi, Saitoh Takayuki, Murakami Hirokazu

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in interleukin 17 (IL17A) and IL-23 receptor (IL23R) are involved in the pathogenesis of many cancers and autoimmune diseases. We investigated the influence of IL17A and IL23R SNPs on the risk of developing multiple myeloma (MM) and its clinical features. We obtained genomic DNA from 120 patients with MM and 201 healthy controls and detected IL17A -197 G/A (rs2275913) and...

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PMID: 28786198
DOI: 10.1002/hon.2469

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Source receipt: pubmed, retrieved 7 Sept 2026.

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