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Article

Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy.

Investigative ophthalmology & visual science - 1 Aug 2017

Amarnani Dhanesh, Machuca-Parra Arturo Israel, Wong Lindsay L, Marko Christina K, Stefater James A, Stryjewski Tomasz P, Eliott Dean, Arboleda-Velasquez Joseph F, Kim Leo A

Abstract excerpt

Purpose: The purpose of this study was to develop a method for isolating, culturing, and characterizing cells from patient-derived membranes in proliferative vitreoretinopathy (PVR) to be used for drug testing. Methods: PVR membranes were obtained from six patients with grade C PVR. Membrane fragments were analyzed by gross evaluation, fixed for immunohistologic studies to establish cell identity, or digested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28777835
DOI: 10.1167/iovs.16-20912
PMCID: PMC5544356

Genes

PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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