Article
Evaluation of high-throughput isomiR identification tools: illuminating the early isomiRome of Tribolium castaneum.
BMC bioinformatics - 3 Aug 2017
Amsel Daniel, Vilcinskas Andreas, Billion André
Abstract excerpt
BACKGROUND: MicroRNAs carry out post-transcriptional gene regulation in animals by binding to the 3' untranslated regions of mRNAs, causing their degradation or translational repression. MicroRNAs influence many biological functions, and dysregulation can therefore disrupt development or even cause death. High-throughput sequencing and the mining of animal small RNA data has shown that microRNA genes can yield...
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