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Article

Molecular events leading to HPV-induced high grade neoplasia

12 Apr 2016

Abstract excerpt

Cervical cancer is initiated by high-risk types of the human papillomavirus (hrHPV) and develops via precursor stages, called cervical intraepithelial neoplasia (CIN). High-grade CIN lesions are considered true precancerous lesions when the viral oncogenes E6 and E7 are aberrantly expressed in the dividing cells. This results in abolishment of normal cell cycle control via p53 and pRb degradation. However, it has...

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PMID: 29074190
DOI: 10.1016/j.pvr.2016.04.003

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