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Persistent Human Papillomavirus Infection

20 Feb 2021

Abstract excerpt

Persistent infection with oncogenic human papillomavirus (HPV) types is responsible for ~5% of human cancers. The HPV infectious cycle can sustain long-term infection in stratified epithelia because viral DNA is maintained as low copy number extrachromosomal plasmids in the dividing basal cells of a lesion, while progeny viral genomes are amplified to large numbers in differentiated superficial cells. The viral...

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PMID: 33672465
DOI: 10.3390/v13020321

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