Flaws in the LNT single-hit model for cancer risk: An historical assessment.

doi:10.1016/j.envres.2017.07.030

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Article

Flaws in the LNT single-hit model for cancer risk: An historical assessment.

Environmental research - 1 Oct 2017

Calabrese Edward J

Abstract excerpt

The LNT single-hit model was derived from the Nobel Prize-winning research of Herman J. Muller who showed that x-rays could induce gene mutations in Drosophila and that the dose response for these so-called mutational events was linear. Lewis J. Stadler, another well-known and respected geneticist at the time, strongly disagreed with and challenged Muller's claims. Detailed evaluations by Stadler over a prolonged...

Topics

Animals
Dose-Response Relationship, Radiation
Drosophila
History, 20th Century
Humans
Models, Genetic
Mutation
Neoplasms
Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 28756009
DOI: 10.1016/j.envres.2017.07.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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