Article
Autoimmunity to Vimentin Is Associated with Outcomes of Patients with Idiopathic Pulmonary Fibrosis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2017
Li Fu Jun, Surolia Ranu, Li Huashi, Wang Zheng, Kulkarni Tejaswini, Liu Gang, de Andrade Joao A, Kass Daniel J, Thannickal Victor J, Duncan Steven R, Antony Veena B
Abstract excerpt
Autoimmunity has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the repertoire of autoantigens involved in this disease and the clinical relevance of these autoimmune responses are still being explored. Our initial discovery assays demonstrated that circulating and intrapulmonary vimentin levels are increased in IPF patients. Subsequent studies showed native vimentin induced...
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