Article
The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies.
Journal of autoimmunity - 1 Nov 2010
Tsuda Masanobu, Torgerson Troy R, Selmi Carlo, Gambineri Eleonora, Carneiro-Sampaio Magda, Mannurita Sara Ciullini, Leung Patrick S C, Norman Gary L, Gershwin M Eric
Abstract excerpt
IPEX syndrome is a congenital disorder of immune regulation caused by mutations in the FOXP3 gene, which is required for the suppressive function of naturally arising CD4 + CD25 + regulatory T cells. In this case series we evaluated serum samples from 12 patients with IPEX syndrome for the presence of common autoantibodies associated with a broad range of autoimmune disorders. We note that 75% of patients (9/12)...
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